Doctoral theses defended in the Faculty of Medicine

Author: Priit Pauklin
Title: Hemodynamic and Biochemical Characteristics of Patients with Atrial Fibrillation and Anticoagulation of ≥65-year-old Patients with Atrial Fibrillation in Estonia
Supervisors: Priit Kampus, Jaan Eha

Author: Triinu Keskpaik
Title: Quality Indicators and Non-Ischemic Myocardial Injury in Emergency Medicine
Supervisors: Joel Starkopf, Peep Talving 

Author: Laura Roht
Title: Hereditary colorectal cancer syndromes in Estonia
Supervisors: Katrin Õunap, Tiina Kahre, Jaan Soplepmann

Author: Liis Ilves
Title: Metabolomic profiling of chronic inflammatory skin diseases
Supervisors: Külli Kingo, Aigar Ottas, Viljar Jaks Paula Reemann

Author: Marit Salus
Title: Effect of sprint interval training on body composition, cardiorespiratory fitness, blood biochemical markers and bone health in adolescent boys with obesity
Supervisors: Jaak Jürimäe, Vallo Tillmann

Author: Ele Hanson
Title: Clinical and biochemical markers for prediction and early diagnosis of pregnancy related complications
Supervisors: Kristiina Rull, Helle Karro, Maris Laan

Author: Jaanus Suumann
Title: Gastric biomarkers and their dynamics as a less invasive method to evaluate stomach health in bariatric surgery patients
Supervisors: Toomas Sillakivi, Ants Peetsalu (kuni 2020)

Author: Kadri Medijainen
Title: Effects of disease-specific physiotherapy on functional performance in patients with mild-to-moderate Parkinson’s disease
Supervisors: Pille Taba, Mati Pääsuke, Aet Lukmann

Author: Stanislav Tjagur
Title: Mycoplasma genitalium and other sexually transmitted infections causing urethritis – their prevalence, impact on male fertility parameters and prostate health
Supervisors: Margus Punab, Reet Mändar

Author: Qurat Ul Ain Reshi
Title: Characterization of the maternal reproductive tract and spermatozoa communication during periconception period via extracellular vesicles
Supervisors: Alireza Fazeli, Andres Salumets, Ülle Jaakma

Author: Kärt Simre
Title: Development of coeliac disease in two populations with different environmental backgrounds 
Supervisors: Raivo Uibo, Oivi Uibo, Vallo Tillmann

Author: Kaspar Ratnik
Title: Development of predictive multimarker test for preeclampsia in early and late pregnancy 
Supervisors: Maris Laan, Kalle Kisand, Kristiina Rull

Author: Maarjaliis Paavo
Title: Short-Wavelength and Near-Infrared Autofluorescence Imaging in Recessive Stargardt Disease, Choroideremia, PROM1-Macular Dystrophy and Ocular Albinism
Supervisors: Kuldar Kaljurand, Janet R Sparrow 

Author: Linda Sõber
Title: Impact of thyroid disease and surgery on patient’s quality of voice and swallowing
Supervisors: Urmas Lepner, Priit Kasenõmm

Author: Risto Vaikjärv
Title: Etiopathogenetic and clinical aspects of peritonsillar abscess
Supervisors: Reet Mändar, Priit Kasenõmm, Siiri Kõljalg, Jelena Štšepetova  

Author: Dissanayake Rallage Keerthie Chulanga Dissanayake
Title: Preimplantation embryo-derived extracellular vesicles: potential as an embryo quality marker and their role during the embryo-maternal communication
Supervisors: Alireza Fazeli, Ülle Jaakma, Andres Salumets, Sulev Kõks

Author: Kasun Madhuranga Godakumara Godagedara
Title: Extracellular vesicle mediated embryo-maternal communication – A tool for evaluating functional competency of pre-implantation embryos 
Supervisors: Alireza Fazeli, Andres Salumets, Ülle Jaakma

Author: Heigo Reima
Title: Colorectal cancer care and outcomes – evaluation and possibilities for improvement in Estonia
Supervisiors: Jaan Soplepmann, Kaire Innos

Author: Liisa Kuhi
Title: A contribution of biomarker collagen type II neoepitope C2C in urine to the diagnosis and prognosis of knee osteoarthritis
Supervisiors: Kalle Kisand, Agu Tamm

Author: Janno Jürgenson
Title: Effect of a 12-week strength training and a competitive half-marathon run on arterial stiffness and blood biochemistry in male welltrained athletes 
Supervisior: Eve Unt

Author: Reeli Tamme
Title: Associations between pubertal hormones and physical activity levels, and subsequent bone mineral characteristics: a longitudinal study of boys aged 12–18
Supervisiors: Vallo Tillmann, Jaak Jürimäe

Author: Mohammad Mehedi Hasan
Title: Characterization of follicular fluid-derived extracellular vesicles and their contribution to periconception environment
Supervisiors: Alireza Fazeli, Ülle Jaakma, Andres Salumets

Author: Priya Kulkarni
Title: Osteoarthritis pathogenesis: an immunological passage through synovium-synovial fluid axis
Supervisiors: Aare Märtson, Sulev Kõks, Abhay Madhukar Harsulkar

Author: Nigul Ilves
Title: Brain plasticity and network reorganization in children with perinatal stroke: a functional magnetic resonance imaging study
Supervisiors: Pilvi Ilves, Rael Laugesaar, Mairi Männamaa

Author: Deniss Sõritsa
Title: The impact of endometriosis and physical activity on female reproduction
Supervisiors: Andres Salumets, Helle Karro, Kadri Matt, Maire Peters

Author: Marko Murruste
Title: Short- and long-term outcomes of surgical management of chronic pancreatitis
Supervisiors: Urmas Lepner, Peep Talving

Author: Jüri Lieberg
Title: Results of surgical treatment and role of biomarkers in pathogenesis and risk prediction in patients with abdominal aortic aneurysm and peripheral artery disease
Supervisior: Jaak Kals

Author: Lille Kurvits
Title: Parkinson’s disease as a multisystem disorder: whole transcriptome study in Parkinson’s disease patients’ skin and blood
Supervisors: Pille Taba, Sulev Kõks, Anu Planken

Author: Liisa Leppik  
Title: Alterations in metabolomic profile of lipids, amino acids and biogenic amines in the early course of schizophrenia spectrum disorders
Supervirors: Liina Haring, Eero Vasar, Mihkel Zilmer

Author: Triin Kikas
Title: Single nucleotide variants affecting placental gene expression and pregnancy outcome
Supervirors: Maris Laan, Kristiina Rull

Author: Hedda Lippus-Metsaots
Title: Interpersonal violence in Estonia: prevalence, impact on health and health behaviour
Supervirors: Helle Karro, Made Laanpere

Author: Pärt Prommik
Title: Hip fracture rehabilitation during 2009–2017 in Estonia
Supervirors: Helgi Kolk, Aare Märtson, Mati Pääsuke

Author: Martin Padar
Title: Enteral nutrition, gastrointestinal dysfunction and intestinal biomarkers in critically ill patients
Supervirors: Joel Starkopf, Annika Reintam Blaser

Author: Siim Schneider
Title: Risk factors, etiology and long-term outcome in young ischemic stroke patients in Estonia
Supervirors: Janika Kõrv, Riina Vibo

Author: Konstantin Ridnõi
Title: Implementation and effectiveness of new prenatal diagnostic strategies in Estonia
Supervirors: Katrin Õunap, Tiia Reimand

Author: Kristiina Ojamaa
Title: Epidemiology of gynecological cancer in Estonia
Supervirors: Kaire Innos, Piret Veerus, Hele Everaus

Author: Marianne Saard
Title: Developing Modern Cognitive Intervention Techniques in Paediatric Neurorehabilitation for Children with Acquired Brain Injury
Superviror: Anneli Kolk

Author: Hardo Lilleväli
Title: Hyperphenylalaninaemias and neurophysiological disorders associated with the condition
Supervisors: Katrin Õunap, Kersti Lilleväli

Author: Roman Balõtšev
Title: Interaction between the immune and metabolic systems in different stages of schizophrenia spectrum disorders
Supervirors: Liina Haring, Eero Vasar, Mihkel Zilmer, Kati Koido

Author: Maarja Hallik
Title: Pharmacokinetics and pharmacodynamics of inotropic drugs in neonates
Supervirors: Tuuli Metsvaht, Joel Starkopf

Author: Raili Müller
Title: Cardiometabolic risk profile and body composition in early rheumatoid arthritis
Supervirors: Riina Kallikorm, Margus Lember, Kaja Põlluste

Author: Sergo Kasvandik
Title: The role of proteomic changes in endometrial cells – from the perspective of fertility and endometriosis
Supervirors: Andres Salumets, Maire Peters, Lauri Peil

Author: Sten Saar
Title: Epidemiology of severe injuries in Estonia
Supervirors: Peep Talving, Urmas Lepner

Author: Kati Braschinsky
Title: Epidemiology of primary headaches in Estonia and applicability of web-based solutions in headache epidemiology research
Superviror: Mark Braschinsky

Author: Helen Vaher
Title: MicroRNAs in the regulation of keratinocyte responses in psoriasis vulgaris and atopic dermatitis
Supervirors: Ana Rebane, Külli Kingo

Author: Liisi Raam
Title: Molecular alterations in the pathogenesis of two chronic dermatoses – vitiligo and psoriasis
Supervirors: Külli Kingo, Kai Kisand, Ana Rebane

Author: Artur Vetkas
Title: Long-term quality of life, emotional  health, and associated factors in patients after aneurysmal subarachnoid haemorrhage
Supervirors: Toomas Asser, Tõnu Rätsep

Author: Teele Kasepalu
Title: Effects of remote ischaemic preconditioning on organ damage and acylcarnitines’ metabolism in vascular surgery
Supervirors: Jaak Kals, Urmas Lepner, Mihkel Zilmer, Joel Starkopf

Author: Pilleriin Soodla
Title: Newly HIV infected people in Estonia: estimation of incidence and transmitted drug resistance
Supervisors: Irja Lutsar, Matti Maimets

Author: Lidiia Zhytnik
Title: Inter- and intrafamilial diversity based on genotype and phenotype correlations of Osteogenesis Imperfecta
Supervisors: Katre Maasalu, Aare Märtson, Sulev Kõks

Author: Toomas Toomsoo
Title: Transcranial brain sonography in the Estonian cohort of Parkinson’s disease
Supervisors: Toomas Asser, Pille Taba, Daniela Berg

Author: Aet Saar
Title: Acute myocardial infarction in Estonia 2001–2014: towards risk based prevention and management
Supervisors: Jaan Eha, Tiia Ainla, Toomas Marandi, Krista Fischer

Author: Ülle Võhma
Title: Association between personality traits, clinical characteristics and pharmacological treatment response in panic disorder
Supervisors: Eduard Maron, Anu Aluoja, Innar Tõru

Author: Kadri Rekker
Title: The putative role of microRNAs in endometriosis pathogenesis and potential in diagnostics
Supervisors: Maire Peters, Andres Salumets, Helle Karro

Author: Maria Yakoreva
Title: Imprinting disorders in Estonia
​​​​​​​Supervisors: Katrin Õunap, Tiina Kahre

Author: Elmira Gurbanova
Title: Specific characteristics of tuberculosis in low default, but high multidrug–resistance prison setting
​​​​​​​Supervisors: Alan Altraja, Kai Blöndal

Author: Aigar Ottas
Title: The metabolomic profiling of psoriasis, atopic dermatitis and atherosclerosis
​​​​​​​Supervisors: Ursel Soomets, Külli Kingo

Author: Kristel Ehala- Aleksejev
Title: The associations between body composition, obesity and obesity-related health and lifestyle conditions with male reproductive function
​​​​​​​Supervisor: Margus Punab

Author: Liis Kadastik-Eerme
Title: Parkinson’s disease in Estonia: epidemiology, quality of life, clinical characteristics and pharmacotherapy
​​​​​​​Supervisors: Pille Taba, Toomas Asser

Author: Mari-Anne Vals
Title: Congenital N-glycosylation disorders in Estonia
Supervisor: Katrin Õunap

Author: Karit Reinson
Title: New diagnostic methods for early detection of inborn errors of metabolism in Estonia
Supervisor: Katrin Õunap

Author: Xuan Dung Ho
Title: Characterization of the genomic profile of osteosarcoma
Supervisors: Aare Märtson, Sulev Kõks, Katre Maasalu

Author: Kärt Kriisa
Title: Profile of acylcarnitines, inflammation and oxidative stress in first-episode psychosis before and after antipsychotic treatment
Supervisors: Liina Haring, Mihkel Zilmer, Eero Vasar

Author: Olga Tšuiko
Title: Unravelling chromosomal instability in mammalian preimplantation embryos using single-cell genomics
Supervisors: Andres Salumets, Joris Robert Vermeesch, Ants Kurg

Author: Janne Tiigimäe-Saar
Title: Botulinum neurotoxin type A treatment for sialorrhea in central nervous system diseases
Supervisors: Tiia Tamme, Pille Taba

Author: Eva Mengel
Title: Longitudinal changes in bone mineral characteristics in boys with obesity and with different body mass index gain during pubertal maturation: associations withbody composition and inflammatory biomarkers 
Supervisors: Jaak Jürimäe, Vallo Tillmann

Author: Kaspar Tootsi
Title: Cardiovascular and metabolomic profiling of osteoarthritis
Supervisors: Aare Märtson, Jaak Kals, Mihkel Zilmer

Author: Mikk Jürisson
Title: Health and economic impact of hip fracture in Estonia
Supervisors: Anneli Uusküla, Riina Kallikorm, Margus Lember

Author: Sander Pajusalu
Title: Genome-wide diagnostics of Mendelian disorders: from chromosomal microarrays to next-generation sequencing
Supervisors: Katrin Õunap, Tiia Reimand

Author: Alar Aab
Title: Insights into molecular mechanisms of asthma and atopic dermatitis
Supervisors: Ana Rebane, Mübeccel Akdis, Külli Kingo

Author: Ott Laius
Title: Utilization of osteoporosis medicines, medication adherence and the trend in osteoporosis related hip fractures in Estonia
Supervisors: Katre Maasalu, Sulev Kõks, Aare Märtson

Author: Živile Riispere
Title: IgA Nephropathy study according the Oxford Classification: IgA Nephropathy clinical-morphological correlations, disease progressioon and the effect of renoprotective therapy
Supervisor: Mai Rosenberg

Author: Binh Ho Duy
Title: Osteogenesis imperfecta in Vietnam
Supervisors: Katre Maasalu, Aare Märtson, Sulev Kõks

Author: Kalev Nõupuu
Title: Autosomal-recessive Stargardt disease: phenotypic heterogeneity and genotype-phenotype associations
​​​​​​​Supervisors: Kuldar Kaljurand, Rando Allikmets

Author: Liina Haring
Title: Cognitive functioning after first psychotic episode
​​​​​​​Supervisors: René Mõttus, Aleksandr Žarkovski, Eduard Maron

Author: Aleksei Rakitin
Title: Metabolic effects of acute and chronic treatment with valproic acid in people with epilepsy
​​​​​​​Supervisors: Sulev Haldre, Sulev Kõks

Author: Georgi Nellis
Title: The use of excipients in medicines administered to neonates in Europe
​​​​​​​Supervisors: Irja Lutsar, Tuuli Metsvaht

Author: Liidia Kiisk
Title: Long-term nutritional study: anthropometrical and clinico-laboratory assessments in renal replacement therapy patients after intensive nutritional counselling
​​​​​​​Supervisors: Helje Kaarma, Mai Rosenberg

Author: Kaido Paapstel
Title: Metabolomic profile of arterial stiffness and early biomarkers of renal damage in atherosclerosis
Supervisors: Jaak Kals, Mihkel Zilmer

Author: Merli Saare
Title: Molecular profiling of endometriotic lesions and endometria of endometriosis patients
Supervisors: Helle Karro, Andres Salumets, Maire Peters