Doctoral theses defended in the Faculty of Medicine

The following doctoral theses have been defended in the Faculty of Medicine since year 2016 (ie since the establishment of the Institute of Clinical Medicine) and they were (co)supervised by the scientists of the Institute of Clinical Medicine:

Author: Priit Pauklin
Title: Hemodynamic and Biochemical Characteristics of Patients with Atrial Fibrillation and Anticoagulation of ≥65-year-old Patients with Atrial Fibrillation in Estonia
Supervisors: Priit Kampus, Jaan Eha

Author: Triinu Keskpaik
Title: Quality Indicators and Non-Ischemic Myocardial Injury in Emergency Medicine
Supervisors: Joel Starkopf, Peep Talving 

Author: Laura Roht
Title: Hereditary colorectal cancer syndromes in Estonia
Supervisors: Katrin Õunap, Tiina Kahre, Jaan Soplepmann

Author: Liis Ilves
Title: Metabolomic profiling of chronic inflammatory skin diseases
Supervisors: Külli Kingo, Aigar Ottas, Viljar Jaks Paula Reemann

Author: Marit Salus
Title: Effect of sprint interval training on body composition, cardiorespiratory fitness, blood biochemical markers and bone health in adolescent boys with obesity
Supervisors: Jaak Jürimäe, Vallo Tillmann

Author: Ele Hanson
Title: Clinical and biochemical markers for prediction and early diagnosis of pregnancy related complications
Supervisors: Kristiina Rull, Helle Karro, Maris Laan

Author: Jaanus Suumann
Title: Gastric biomarkers and their dynamics as a less invasive method to evaluate stomach health in bariatric surgery patients
Supervisors: Toomas Sillakivi, Ants Peetsalu (kuni 2020)

Author: Kadri Medijainen
Title: Effects of disease-specific physiotherapy on functional performance in patients with mild-to-moderate Parkinson’s disease
Supervisors: Pille Taba, Mati Pääsuke, Aet Lukmann

Author: Stanislav Tjagur
Title: Mycoplasma genitalium and other sexually transmitted infections causing urethritis – their prevalence, impact on male fertility parameters and prostate health
Supervisors: Margus Punab, Reet Mändar

Author: Qurat Ul Ain Reshi
Title: Characterization of the maternal reproductive tract and spermatozoa communication during periconception period via extracellular vesicles
Supervisors: Alireza Fazeli, Andres Salumets, Ülle Jaakma

Author: Kärt Simre
Title: Development of coeliac disease in two populations with different environmental backgrounds 
Supervisors: Raivo Uibo, Oivi Uibo, Vallo Tillmann

Author: Kaspar Ratnik
Title: Development of predictive multimarker test for preeclampsia in early and late pregnancy 
Supervisors: Maris Laan, Kalle Kisand, Kristiina Rull

Author: Maarjaliis Paavo
Title: Short-Wavelength and Near-Infrared Autofluorescence Imaging in Recessive Stargardt Disease, Choroideremia, PROM1-Macular Dystrophy and Ocular Albinism
Supervisors: Kuldar Kaljurand, Janet R Sparrow 

Author: Linda Sõber
Title: Impact of thyroid disease and surgery on patient’s quality of voice and swallowing
Supervisors: Urmas Lepner, Priit Kasenõmm

Author: Risto Vaikjärv
Title: Etiopathogenetic and clinical aspects of peritonsillar abscess
Supervisors: Reet Mändar, Priit Kasenõmm, Siiri Kõljalg, Jelena Štšepetova  

Author: Dissanayake Rallage Keerthie Chulanga Dissanayake
Title: Preimplantation embryo-derived extracellular vesicles: potential as an embryo quality marker and their role during the embryo-maternal communication
Supervisors: Alireza Fazeli, Ülle Jaakma, Andres Salumets, Sulev Kõks

Author: Kasun Madhuranga Godakumara Godagedara
Title: Extracellular vesicle mediated embryo-maternal communication – A tool for evaluating functional competency of pre-implantation embryos 
Supervisors: Alireza Fazeli, Andres Salumets, Ülle Jaakma

Author: Heigo Reima
Title: Colorectal cancer care and outcomes – evaluation and possibilities for improvement in Estonia
Supervisiors: Jaan Soplepmann, Kaire Innos

Author: Liisa Kuhi
Title: A contribution of biomarker collagen type II neoepitope C2C in urine to the diagnosis and prognosis of knee osteoarthritis
Supervisiors: Kalle Kisand, Agu Tamm

Author: Janno Jürgenson
Title: Effect of a 12-week strength training and a competitive half-marathon run on arterial stiffness and blood biochemistry in male welltrained athletes 
Supervisior: Eve Unt

Author: Reeli Tamme
Title: Associations between pubertal hormones and physical activity levels, and subsequent bone mineral characteristics: a longitudinal study of boys aged 12–18
Supervisiors: Vallo Tillmann, Jaak Jürimäe

Author: Mohammad Mehedi Hasan
Title: Characterization of follicular fluid-derived extracellular vesicles and their contribution to periconception environment
Supervisiors: Alireza Fazeli, Ülle Jaakma, Andres Salumets

Author: Priya Kulkarni
Title: Osteoarthritis pathogenesis: an immunological passage through synovium-synovial fluid axis
Aare Märtson, Sulev Kõks, Abhay Madhukar Harsulkar

Author: Nigul Ilves
Title: Brain plasticity and network reorganization in children with perinatal stroke: a functional magnetic resonance imaging study
Supervisiors: Pilvi Ilves, Rael Laugesaar, Mairi Männamaa

Author: Deniss Sõritsa
Title: The impact of endometriosis and physical activity on female reproduction
Supervisiors: Andres Salumets, Helle Karro, Kadri Matt, Maire Peters

Author: Marko Murruste
Title: Short- and long-term outcomes of surgical management of chronic pancreatitis
Supervisiors: Urmas Lepner, Peep Talving

Author: Jüri Lieberg
Title: Results of surgical treatment and role of biomarkers in pathogenesis and risk prediction in patients with abdominal aortic aneurysm and peripheral artery disease
Supervisior: Jaak Kals

Author: Lille Kurvits
Title: Parkinson’s disease as a multisystem disorder: whole transcriptome study in Parkinson’s disease patients’ skin and blood
Supervisors: Pille Taba, Sulev Kõks, Anu Planken

Author: Liisa Leppik  
Title: Alterations in metabolomic profile of lipids, amino acids and biogenic amines in the early course of schizophrenia spectrum disorders
Supervirors: Liina Haring, Eero Vasar, Mihkel Zilmer

Author: Triin Kikas
Title: Single nucleotide variants affecting placental gene expression and pregnancy outcome
Supervirors: Maris Laan, Kristiina Rull

Author: Hedda Lippus-Metsaots
Title: Interpersonal violence in Estonia: prevalence, impact on health and health behaviour
Supervirors: Helle Karro, Made Laanpere

Author: Pärt Prommik
Title: Hip fracture rehabilitation during 2009–2017 in Estonia
Supervirors: Helgi Kolk, Aare Märtson, Mati Pääsuke

Author: Martin Padar
Title: Enteral nutrition, gastrointestinal dysfunction and intestinal biomarkers in critically ill patients
Supervirors: Joel Starkopf, Annika Reintam Blaser

Author: Siim Schneider
Title: Risk factors, etiology and long-term outcome in young ischemic stroke patients in Estonia
Supervirors: Janika Kõrv, Riina Vibo

Author: Konstantin Ridnõi
Title: Implementation and effectiveness of new prenatal diagnostic strategies in Estonia
Supervirors: Katrin Õunap, Tiia Reimand

Author: Kristiina Ojamaa
Title: Epidemiology of gynecological cancer in Estonia
Supervirors: Kaire Innos, Piret Veerus, Hele Everaus

Author: Marianne Saard
Title: Developing Modern Cognitive Intervention Techniques in Paediatric Neurorehabilitation for Children with Acquired Brain Injury
Superviror: Anneli Kolk

Author: Hardo Lilleväli
Title: Hyperphenylalaninaemias and neurophysiological disorders associated with the condition
Supervisors: Katrin Õunap, Kersti Lilleväli

Author: Roman Balõtšev
Title: Interaction between the immune and metabolic systems in different stages of schizophrenia spectrum disorders
Supervirors: Liina Haring, Eero Vasar, Mihkel Zilmer, Kati Koido

Author: Maarja Hallik
Title: Pharmacokinetics and pharmacodynamics of inotropic drugs in neonates
Supervirors: Tuuli Metsvaht, Joel Starkopf

Author: Raili Müller
Title: Cardiometabolic risk profile and body composition in early rheumatoid arthritis
Supervirors: Riina Kallikorm, Margus Lember, Kaja Põlluste

Author: Sergo Kasvandik
Title: The role of proteomic changes in endometrial cells – from the perspective of fertility and endometriosis
Supervirors: Andres Salumets, Maire Peters, Lauri Peil

Author: Sten Saar
Title: Epidemiology of severe injuries in Estonia
Supervirors: Peep Talving, Urmas Lepner

Author: Kati Braschinsky
Title: Epidemiology of primary headaches in Estonia and applicability of web-based solutions in headache epidemiology research
Superviror: Mark Braschinsky

Author: Helen Vaher
Title: MicroRNAs in the regulation of keratinocyte responses in psoriasis vulgaris and atopic dermatitis
Supervirors: Ana Rebane, Külli Kingo

Author: Liisi Raam
Title: Molecular alterations in the pathogenesis of two chronic dermatoses – vitiligo and psoriasis
Supervirors: Külli Kingo, Kai Kisand, Ana Rebane

Author: Artur Vetkas
Title: Long-term quality of life, emotional  health, and associated factors in patients after aneurysmal subarachnoid haemorrhage
Supervirors: Toomas Asser, Tõnu Rätsep

Author: Teele Kasepalu
Title: Effects of remote ischaemic preconditioning on organ damage and acylcarnitines’ metabolism in vascular surgery
Supervirors: Jaak Kals, Urmas Lepner, Mihkel Zilmer, Joel Starkopf

Author: Pilleriin Soodla
Title: Newly HIV infected people in Estonia: estimation of incidence and transmitted drug resistance
Supervisors: Irja Lutsar, Matti Maimets

Author: Lidiia Zhytnik
Title: Inter- and intrafamilial diversity based on genotype and phenotype correlations of Osteogenesis Imperfecta
Supervisors: Katre Maasalu, Aare Märtson, Sulev Kõks

Author: Toomas Toomsoo
Title: Transcranial brain sonography in the Estonian cohort of Parkinson’s disease
Supervisors: Toomas Asser, Pille Taba, Daniela Berg

Author: Aet Saar
Title: Acute myocardial infarction in Estonia 2001–2014: towards risk based prevention and management
Supervisors: Jaan Eha, Tiia Ainla, Toomas Marandi, Krista Fischer

Author: Ülle Võhma
Title: Association between personality traits, clinical characteristics and pharmacological treatment response in panic disorder
Supervisors: Eduard Maron, Anu Aluoja, Innar Tõru

Author: Kadri Rekker
Title: The putative role of microRNAs in endometriosis pathogenesis and potential in diagnostics
Supervisors: Maire Peters, Andres Salumets, Helle Karro

Author: Maria Yakoreva
Title: Imprinting disorders in Estonia
​​​​​​​Supervisors: Katrin Õunap, Tiina Kahre

Author: Elmira Gurbanova
Title: Specific characteristics of tuberculosis in low default, but high multidrug–resistance prison setting
​​​​​​​Supervisors: Alan Altraja, Kai Blöndal

Author: Aigar Ottas
Title: The metabolomic profiling of psoriasis, atopic dermatitis and atherosclerosis
​​​​​​​Supervisors: Ursel Soomets, Külli Kingo

Author: Kristel Ehala- Aleksejev
Title: The associations between body composition, obesity and obesity-related health and lifestyle conditions with male reproductive function
​​​​​​​Supervisor: Margus Punab

Author: Liis Kadastik-Eerme
Title: Parkinson’s disease in Estonia: epidemiology, quality of life, clinical characteristics and pharmacotherapy
​​​​​​​Supervisors: Pille Taba, Toomas Asser

Author: Mari-Anne Vals
Title: Congenital N-glycosylation disorders in Estonia
Supervisor: Katrin Õunap

Author: Karit Reinson
Title: New diagnostic methods for early detection of inborn errors of metabolism in Estonia
Supervisor: Katrin Õunap

Author: Xuan Dung Ho
Title: Characterization of the genomic profile of osteosarcoma
Supervisors: Aare Märtson, Sulev Kõks, Katre Maasalu

Author: Kärt Kriisa
Title: Profile of acylcarnitines, inflammation and oxidative stress in first-episode psychosis before and after antipsychotic treatment
Supervisors: Liina Haring, Mihkel Zilmer, Eero Vasar

Author: Olga Tšuiko
Title: Unravelling chromosomal instability in mammalian preimplantation embryos using single-cell genomics
Supervisors: Andres Salumets, Joris Robert Vermeesch, Ants Kurg

Author: Janne Tiigimäe-Saar
Title: Botulinum neurotoxin type A treatment for sialorrhea in central nervous system diseases
Supervisors: Tiia Tamme, Pille Taba

Author: Eva Mengel
Title: Longitudinal changes in bone mineral characteristics in boys with obesity and with different body mass index gain during pubertal maturation: associations withbody composition and inflammatory biomarkers 
Supervisors: Jaak Jürimäe, Vallo Tillmann

Author: Kaspar Tootsi
Title: Cardiovascular and metabolomic profiling of osteoarthritis
Supervisors: Aare Märtson, Jaak Kals, Mihkel Zilmer

Author: Mikk Jürisson
Title: Health and economic impact of hip fracture in Estonia
Supervisors: Anneli Uusküla, Riina Kallikorm, Margus Lember

Author: Sander Pajusalu
Title: Genome-wide diagnostics of Mendelian disorders: from chromosomal microarrays to next-generation sequencing
Supervisors: Katrin Õunap, Tiia Reimand

Author: Alar Aab
Title: Insights into molecular mechanisms of asthma and atopic dermatitis
Supervisors: Ana Rebane, Mübeccel Akdis, Külli Kingo

Author: Ott Laius
Title: Utilization of osteoporosis medicines, medication adherence and the trend in osteoporosis related hip fractures in Estonia
Supervisors: Katre Maasalu, Sulev Kõks, Aare Märtson

Author: Živile Riispere
Title: IgA Nephropathy study according the Oxford Classification: IgA Nephropathy clinical-morphological correlations, disease progressioon and the effect of renoprotective therapy
Supervisor: Mai Rosenberg

Author: Binh Ho Duy
Title: Osteogenesis imperfecta in Vietnam
Supervisors: Katre Maasalu, Aare Märtson, Sulev Kõks

Author: Kalev Nõupuu
Title: Autosomal-recessive Stargardt disease: phenotypic heterogeneity and genotype-phenotype associations
​​​​​​​Supervisors: Kuldar Kaljurand, Rando Allikmets

Author: Liina Haring
Title: Cognitive functioning after first psychotic episode
​​​​​​​Supervisors: René Mõttus, Aleksandr Žarkovski, Eduard Maron

Author: Aleksei Rakitin
Title: Metabolic effects of acute and chronic treatment with valproic acid in people with epilepsy
​​​​​​​Supervisors: Sulev Haldre, Sulev Kõks

Author: Georgi Nellis
Title: The use of excipients in medicines administered to neonates in Europe
​​​​​​​Supervisors: Irja Lutsar, Tuuli Metsvaht

Author: Liidia Kiisk
Title: Long-term nutritional study: anthropometrical and clinico-laboratory assessments in renal replacement therapy patients after intensive nutritional counselling
​​​​​​​Supervisors: Helje Kaarma, Mai Rosenberg

Author: Kaido Paapstel
Title: Metabolomic profile of arterial stiffness and early biomarkers of renal damage in atherosclerosis
Supervisors: Jaak Kals, Mihkel Zilmer

Author: Merli Saare
Title: Molecular profiling of endometriotic lesions and endometria of endometriosis patients
Supervisors: Helle Karro, Andres Salumets, Maire Peters